J&J's Tremfya grabs psoriatic arthritis nod, setting up a battle with Cosentyx, Taltz and more

Tremfya was initially approved to treat plaque psoriasis. (J&J)

Johnson & Johnson is battling giants in the immunology field with its IL-23 inhibitor Tremfya. With other next-gen drugs already crowding the market, J&J now has the FDA's nod to take Tremfya into psoriatic arthritis in what could prove to be a tough challenge. 

The FDA on Tuesday approved J&J's Tremfya as the first IL-23 inhibitor to treat psoriatic arthritis, which affects around 1.5 million Americans each year, the drugmaker said. 

The agency based its review on data from two pivotal phase 3 trials showing Tremfya topped placebo in the number of psoriatic arthritis patients who showed 20% improvement in disease symptoms at the 24-week mark. 

Sept. 15-17,2020

Cytiva Virtual Event: Tapas & Tech Talks Copy - Strategies for robust and scalable

Strategies for robust and scalable processes: from research through late-stage trials
(with Cytiva and IQVIA)

In the two studies from J&J's Discover program, 58% of patients were also treated with immunosuppressant methotrexate. One of the studies only included patients who had not been previously treated with a biologic while the other enrolled 31% of patients who had previously been treated with an anti-TNF drug. 

Tremfya is administered under the skin in eight-week intervals after patients receive starter doses at the initiation of treatment and the four-week mark, J&J said. 

RELATED: Johnson & Johnson's Tremfya backs psoriatic arthritis play with newest data

Suggested Articles

WuXi Biologics has tapped its former Chinese facility head as CEO of its still-in-the-works vaccines CDMO unit in Ireland.

After a slow start, Teva's Ajovy launch is improving following the FDA approval for an autoinjector.

After Trump's "Buy American" executive order for essential medicines, the pharma industry is pushing back.