Texas Biomed leads transatlantic group in $23M HIV vaccine effort

Dr. Ruth Ruprecht, director of the Texas Biomed AIDS Research Program

An HIV vaccine research team led by Texas Biomedical Research Institute has secured $23 million in NIH grant funding to explore an approach that’ll utilize three lines of defense to protect against the virus.

As part of the 5-year project with three phases, the scientists want to develop a vaccine that can block HIV where it infiltrates the body at the mucosa while also creating a backup response throughout the blood and tissue.

First, the group will examine how HIV moves through mucus and mucosal fluids and how it passes through epithelial barriers. For the second portion, the group plans to build on previous work in immune exclusion to prevent the virus from crossing epithelial barrier. Lastly, Dr. Darrell Irvine from MIT will lead efforts in vaccine design.

Survey

Survey: The Critical Role of Innovation in Launching Successful OTC Products

This research aims to understand the importance of product innovation and dose forms in driving new product design and development, consumer engagement and purchase interest for Over-the-Counter medicines. The first 50 qualified respondents will receive a $5 Amazon gift card. Take the survey now.

The group takes inspiration for the plan from the military tactic “defense-in-depth” which stresses to protect an area even after a frontline is overrun, according to a release.

It’s the latest in a series of developments in a fast-moving HIV vaccines field as projects around the world take shape. In May, the NIH said it planned to initiate a large-scale trial later this year in South Africa, building on a 2009 study in Thailand of the vaccine RV144.

Just last week, Johnson & Johnson said it completed enrollment for a Phase I/IIa trial of 400 volunteers in South Africa, Rwanda, Uganda, Thailand and the United States, Business Insider reported. It also has plans to enroll for another early trial.

Elsewhere, Duke last year grabbed $20 million in NIH funding to conduct its HIV vaccine research, and TSRI, and the University of Maryland have all progressed with candidates. Last fall, the European Commission started a €23 million collaboration between 22 organizations and companies hoping to contribute in efforts toward an HIV vaccine.

- here's the release
- more from Business Insider

Related Articles:
NIH to launch large-scale HIV vaccine trial in South Africa
Duke, NIAID track HIV evolution with eyes on creating a vaccine
European Commission launches €23M HIV vaccine research initiative
HIV vaccine research a 'major advance,' NIH official says

Read more on

Suggested Articles

AstraZeneca has had high hopes for its Imfinzi-tremelimumab pairing. But after a high-profile miss last year, the combo has struck out again.

Already knocked by the FDA four times this year, Dr. Reddy’s now has a fifth Form 483 to dwell on. This time it’s at a plant with a history of faults.

Kinase inhibitors to treat cancer have driven nearly $100 billion in deals since 2010, a trend that's likely to grow, SVB Leerink analysts predict.