GSK executives change their tune as AZ, Sanofi heap pressure on respiratory hopeful Nucala

GlaxoSmithKline's Nucala is feeling the effects of stiff competition from AstraZeneca's Fasenra. (GlaxoSmithKline)

A lot has changed in the severe asthma market lately—including the way GlaxoSmithKline is talking about its contender, Nucala.

On the company’s third-quarter conference call last week, the British drugmaker’s pharma chief, Luke Miels, told investors the company had “very much held” AstraZeneca newcomer Fasenra “in place in Japan and Europe.”

“I’m very encouraged by that,” he said, adding, “we can compete.”

Free Daily Newsletter

Like this story? Subscribe to FiercePharma!

Biopharma is a fast-growing world where big ideas come along daily. Our subscribers rely on FiercePharma as their must-read source for the latest news, analysis and data on drugs and the companies that make them. Sign up today to get pharma news and updates delivered to your inbox and read on the go.

RELATED: GlaxoSmithKline's Nucala, buoyed by its medical organization, ready to 'fiercely compete' with AstraZeneca

That’s quite a tone-down from last year, when Cheryl MacDiarmid, GSK’s senior vice president of primary care, told FiercePharma the company was “ready to fiercely compete” to retain the market lead it built up during a two-year head start.

“It’s a challenge having someone new come to the market, but it’s also an exciting moment because it makes sure that we’re on our 'A' game,” she said at the time.

To hear Miels tell it, though, the company wasn’t on its A-game when Fasenra launched at all. “The fact remains we're not getting enough with these patients in the U.S., and I put that down to more execution rather than data,” he said.

The way he sees it, “if you go back 12 months ago, I think we were very much behind on several parameters in terms of the perception of Nucala versus Fasenra,” he said on the call. Doctors were more interested in the AZ drug’s speed of onset and mechanism of action than GSK figured they would be, forcing Glaxo to go back and double down on its messaging.

SPECIAL REPORT: Top 15 pharma companies by 2017 revenue | GlaxoSmithKline

There’s one Fasenra advantage that can’t be “neutralized,” though, as Miels put it. Nucala is dosed every four weeks, while Fasenra only needs to be taken once every eight. And that’s why Glaxo is pinning its hopes on an autoinjector for at-home use that’ll improve Nucala’s convenience, on track to roll out next year.

Until then, though, “we’re expecting growth for the next few quarters to be a bit more challenging,” CFO Simon Dingemans said on the call.

Glaxo isn’t taking the new rivalry lying down, of course. “We have changed some key members of the Nucala team in the U.S.” and “increased the resources behind that product,” and there’s more to come, too. “We'll be engaging in a more focused way with doctors, driving our message of long-lasting protection from exacerbations,” Miels said.

Following its recent about-face on paid speaking engagement for docs, Glaxo also wrapped an external speaker event at the American College of Chest Physicians’ CHEST annual meeting.

RELATED: Sanofi's Dupixent set for $2.5B in peak asthma sales after scoring winning label: analyst

The thing is, it’s not just Fasenra that’ll be giving Nucala trouble down the line—and GSK knows it. In October, Sanofi’s Dupixent picked up a severe asthma nod of its own, and analysts predict it’ll add $2.5 billion to peak sales.

“This is very much a three-dog fight between us and Fasenra and Dupixent,” Miels said, adding, “I think if we keep working on these things and we can neutralize the dosing frequency, then in the second half of 2019, I'm more optimistic. But we have to be realistic in the short term.”

Suggested Articles

Industry watchers have been speculating about just how high Novartis would price gene therapy Zolgensma. And now, they have an answer.

The WHO’s role in part is to provide prescribing guidance without an eye on profits. What happens when that guidance is tainted by private money?

After 19 sales reps left Amgen to help Karyopharm launch a rival multiple myeloma drug, Amgen sued. Now Karyopharm wants the suit thrown out.