Keyword: United Therapeutics

12. Remodulin

For a smaller pharma company like United Therapeutics, losing patent protection on a big drug is especially painful. Remodulin, approved in 2002, loses exclusivity this summer, meaning the company will soon face off against cheap competition to its biggest top-line contributor.

10. Remodulin

United Therapeutics was built on Remodulin. The company grew out of a career change for CEO Martine Rothblatt, who built Sirius satellite radio before getting into pharma. Her son’s diagnosis of pulmonary arterial hypertension inspired the move—and Remodulin, which was approved in 2002.