North Carolina State researchers 'smuggle' drugs into cancer cells with ATP

Delivery of cancer drugs using ATP in an endosome and lysosome--Courtesy of NC State

North Carolina State researchers have developed a method to "smuggle" cancer drugs into cancer cells, enabling delivery of the treatment within the cell itself. The technique involves multiple liposomes containing ATP and another containing the cancer drug called doxorubicin, all trapped within an endosome. The ATP is released within the endosome, triggering the release of doxorubicin and creating an opening in the endosome, causing the drug to spread within the cell and eventually kill it. More

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