Encapsulation of fecal matter achieved for treatment of infected colons

Fecal microbiota transplantation enables the reconstitution of gut bacteria, and has been proven effective to treat Clostridium difficile infections of the colon. But, as you can imagine, the nature of the active ingredient presents a tough drug delivery challenge. Luckily, the field is advancing. Many reported transplantations have been conducted using fresh stool suspensions. The use of frozen fecal matter delivered via a nasogastric tube from the nasal passages to the stomach is another option. Now, researchers have created a capsule version of the product that enables oral delivery and eliminates the need for surgery. It performed well in initial studies of safety and effectiveness, according to an article in the Journal of the American Medical Association. News release | Study

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