Still stuck in Orkambi talks, Vertex CEO preps for mano a mano with British health secretary

Vertex Pharma
Vertex executives traveled to the United Kingdom on Thursday for a parliamentary hearing on CF drug prices. (Vertex Pharma)

Vertex and English health authorities have been deadlocked in pricing negotiations for cystic fibrosis drug Orkambi for years. Now, "finally," as Vertex CEO Jeffrey Leiden put it at a Thursday hearing, the helmsman has a face to face meeting set with Britain's health secretary Matt Hancock. 

Leiden and Hancock plan to meet Monday to discuss the issue, Leiden said at a hearing of the U.K. Parliament’s Health and Social Care Committee.

Such meetings aren't usual in pricing negotiations in England, but this negotiation has been far from usual. Vertex and British officials have been in a high-profile tug-of-war over Orkambi's price for years, with patient advocates protesting the delay and local media tracking every move.

Free Webinar

Striving for Zero in Quality & Manufacturing

Pharmaceutical and medical device manufacturers strive towards a culture of zero – zero hazards, zero defects, and zero waste. This webinar will discuss the role that content management plays in pharmaceutical manufacturing to help companies reach the goal of zero in Quality and Manufacturing.

Leiden said he'll bring "new ideas" to the meeting, including a proposal that the two sides agree on an Orkambi discount to give patients immediate access to the drug while their cost-effectiveness talks continue. That immediate discount could be on par with Scotland's negotiated price break, Leiden said.

As public pressure escalates and months tick by, the parliamentary committee kicked off a probe into why the sides can't reach a deal. On Thursday the panel heard from officials with NHS England, cost watchdogs at NICE, patients and advocates, and Vertex executives.

At the hearing, the two sides couldn't even agree on which group ended the most recent round of negotiations. NICE director Andrew Dillon said Vertex isn’t engaging, and Leiden said NHS “walked away” in July 2018. And obviously, they disagreed on the value of Orkambi, approved in Europe in 2015 but still not routinely available in England.

RELATED: Vertex CEO, CCO head for U.K. hearing on Orkambi pricing standoff 

Still, Vertex executives and English health officials said Thursday that they're ready to work together now to get Orkambi to patients. At the hearing, officials asked Vertex to accept its current offer of £500 million over five years and £1 billion over 10 years for access to all its CF drugs. The two sides can negotiate another deal when Vertex's "triple combo" comes up for review.

The U.K. has the world's largest population of CF patients, so Vertex has made its best offer, Leiden said. Still, the sides aren't close on their proposed prices, officials said. Dillon said almost every other company demonstrates flexibility in pricing negotiations, calling Vertex an "outlier."

Leiden didn't favor the solution offered up Thursday. He said he hopes Hancock will endorse a deal similar to Vertex's recent contract with Scotland. On the outlier comment, Leiden said Vertex has struck Orkambi pricing deals with 17 countries, including in Ireland and Australia, whose procurement systems are similar to England's. England is the anomaly in this scenario, he said, adding that officials there are trying to secure a 90% discount compared to pricing in other European countries.

RELATED: Vertex says it's glad England made another offer for CF drugs, but it'll have to do better 

Despite the numerous disagreements, Leiden said Vertex is “eager” to work with England to adjust their cost-effectiveness reviews. If English officials agree to work with Vertex, Leiden said he’s “very optimistic” the sides can reach a deal.

After NHS England made its “largest ever” commitment last year, Vertex said the proposal "does not take into account the vast time and resources invested” to develop the drugs. An executive added that it could hamper the company's ability to one day find a cure for the disease.

Suggested Articles

It's taken years for Amarin's Vascepa to prove itself as a game-changing treatment for CV disease. An FDA committee may have just punched its pass.

Continuing its expansion efforts, Japan’s Fujifilm will make a major investment in its U.S. gene therapy operation in Texas.

With a potential approval next year in the up-and-coming NASH field, Intercept is staffing up its sales team and starting talks with payers.