Merck looks for leg up on Bristol with Keytruda's latest colorectal cancer win

Keytruda
Merck's Keytruda topped chemo at staving off cancer progression in a group of colorectal cancer patients. (Merck)

Merck’s Keytruda went up against chemo in a head-to-head colorectal cancer battle—and won.

The immuno-oncology star trumped various chemo regimens at keeping cancer from progressing in previously untreated patients with microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer that had either spread to other parts of the body or couldn’t be surgically removed, the New Jersey drugmaker said Tuesday.

RELATED: Merck's Keytruda wins first FDA nod to treat genetically ID'd tumors anywhere in the body

On-Demand Webinar

Leveraging A Medical Record-Enriched Patient Dataset for COVID-19 Research

You are invited to join a webinar that will explore the ways researchers can leverage this enriched dataset for important COVID-19 research. Sign up today for this informative webinar to learn how you can leverage one of the only medical record reviews solely using real-world data from hospitalized COVID-19 patients.

As Merck was quick to note, the trial, Keynote-177, was the first phase 3 trial to successfully pit a single-agent therapy against the standard of care—a combination of Roche’s Avastin and a chemo regimen known as mFOLFOX6. “We look forward to sharing these data as quickly as possible with the medical community and regulatory authorities,” Roy Baynes, Merck SVP and global head of clinical development, said in a statement.

In the meantime, the study will continue to see if Keytruda can extend patient lives to hit its second primary endpoint.

An approval for Keytruda in the previously untreated group would broaden the reach it already has in MSI-H and dMMR tumors. Back in May 2017, it picked up an FDA green light in previously treated patients whose tumors bore those biomarkers, no matter where the tumors were located within the body.

RELATED: Bristol-Myers Squibb eyes lead in rare colorectal cancer with new Opdivo results

It would also give Keytruda a leg up over rival Bristol Myers Squibb rival Opdivo in the colorectal field. The BMS contender boasts its own approval for previously treated MSI-H or dMMR colorectal cancer, but it hasn’t yet broken into the front-line setting.

That doesn’t mean it’s not trying. In October 2018, Bristol rolled out phase 2 results showing its Opdivo-Yervoy pairing could provoke responses in 60% of first-line MSI-H or dMMR colorectal cancer patients, a result BMS’ oncology development chief, Fouad Namouni, called “groundbreaking.”

Suggested Articles

Life sciences companies have pivoted quickly during COVID-19 - Syneos Health® is supporting more than 80 active COVID-19 projects, including vaccines.

New York's Covaxx has signed on with three South American nations to provide 140 million doses of its early-stage COVID-19 vaccine.

To get the COVID-19 vaccine out quickly, Pfizer has been running rehearsals at distribution sites, creating "growing confidence," U.S. officials said.