AZ's Iressa rejected by Scottish cost regulators; Mylan sells $1.25B worth of senior notes;

 @FiercePharma: Takeda plots 1,400 job cuts at U.S. ops. Article | Follow @FiercePharma

> AstraZeneca's cancer drug Iressa has suffered a further setback in the U.K. after cost regulators rejected its use on NHS Scotland as a treatment for patients with non-small cell lung cancer. Report

> Mylan on Wednesday sold $1.25 billion of senior notes in two parts in the 144a private placement market, says IFR, a Thomson Reuters service. Report

> Medco Health Solutions says it planned to buy back $3 billion more of its stock as it finishes a share repurchase program of the same amount. Release | Report

> CVS Caremark says Chairman and CEO Thomas Ryan will retire next year, and its board has picked retail executive Larry Merlo to succeed him. Release | Report

> Bosnian pharmaceuticals company Bosnalijek reported flat net profit in the first quarter of 1.1 million Bosnian marka on revenue down 11 percent at 21.7 million marka ($14 million). Release | Report

> The FDA is warning consumers about potentially serious side effects from mistakenly swallowing Benadryl Extra Strength Itch Stopping Gel, an over-the-counter product that should only be used on the skin. Release

> Ranbaxy Laboratories, controlled by Japan's Daiichi Sankyo, plans to sell stakes in group companies of its founder to raise about 3 billion rupees ($67 million), the Economic Times reports. Report

Biotech News

 @FierceBiotech: Troubled Genzyme launches probe into insider trading claims. Article | Follow @FierceBiotech

 @JohnCFierce: 15 VC-backed companies traded hands last week. So is the party back on yet? Nope. Report  | Follow @JohnCFierce

> NicOx share price dive as expert panel spurn naproxcinod. Story

> DNA nanobots can assemble particles, follow instructions. Item

> Struggling GTC faced with dwindling cash reserves. Article

Manufacturing News

> My Job: Board member, Intelleflex. Item

> FDA makes REMS a drug approval staple. Report

> Corporate green goals driving PAT adoption. News

> FDA drafts pharma exec prosecution guidelines. Article

> J&J, Teva show different manufacturing responsibility styles. Report

Vaccines News

> Chinese editor sacked for vax safety story. Report

> Archivel touts vax for latent TB. Story

> Gates Foundation grants help fuel vaccine projects. News

> GSK under fire for delay of new vax program. Article

And Finally ... Drugs already approved for the treatment of erectile dysfunction may actually help boost the effectiveness of treatments for brain tumors tied to both lung and breast cancer. Report