AHA: Amgen's Repatha tied to greater risk reduction in high-risk heart attack patients

Amgen's Repatha was found to be more effective in reducing follow-up cardiovascular events in high-risk heart attack patients. (Amgen)

PHILADELPHIA—With new competition potentially on its way in the PCSK9 inhibitor class, Amgen's stalwart Repatha is looking for a leg up in treating high-risk heart attack patients.

A new analysis shows that patients within the one-year mark of a heart attack are at a much higher risk of a following cardiovascular event––and cholesterol-lowering Repatha is particularly effective in treating that group.

Patients treated with a Repatha-statin combo within one year after a heart attack showed a 25% risk reduction in follow-up CV events, including heart attack, death or stroke, over statins alone. In patients treated with the combo after the one-year mark, there was a reported 15% risk reduction, according to an analysis of data from Amgen's Fourier outcomes trial set to be presented Monday at the American Heart Association's Scientific Sessions. 


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Chris Kurtz, Amgen's vice president and global development and therapeutic area head for cardiovascular and metabolic, reinforced Repatha's clinical effect on high-risk heart attack patients by intensively lowering LDL-C levels. 

"It’s good that we have validation, but it's maybe not a surprising result," Kurtz said. "I would say there’s a growing body of evidence that there’s urgency around risk-factor control and LDL reduction, and now we have tools to do it."

RELATED: Amgen escalates PCSK9 pricing war with permanent 60% price cut on Repatha

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