Chugai, PharmaMar post positive blood cancer results for new sea squirt drug

Tokyo-based Chugai Pharmaceutical and research partner PharmaMar have announced that their investigational new multiple myeloma drug that has been developed from a marine animal significantly increased survival in certain patients.

Chugai's Tokyo headquarters


Striving for Zero in Quality & Manufacturing

Pharmaceutical and medical device manufacturers strive towards a culture of zero – zero hazards, zero defects, and zero waste. This on-demand webinar discusses the role that content management plays in pharmaceutical manufacturing to help companies reach the goal of zero in Quality and Manufacturing.

The Japanese company, which is majority owned by Switzerland's Roche ($RHHBY), announced that its Phase III clinical trial of Aplidin (plitidepsin) with dexamethasone--versus dexamethasone alone--in patients with relapsed/refractory multiple myeloma met its primary endpoint after posting a statistically significant extension in PFS when compared with dexamethasone alone.

In fact the data show that the treatment reduced the risk of progression or death by 35%.

The study was conducted by its partner for the drug, the Spanish cancer specialist PharmaMar. Chugai bought promotion rights of Aplidin for the treatment of multiple myeloma in 8 European countries in a tie-up with PharmaMar back in 2014.

"This is a positive step forward for our shared vision with PharmaMar to introduce a new treatment for relapsed multiple myeloma and we are confident that Aplidin's mechanism of action and strong supporting data will lead to a successful introduction of this novel drug for the benefit of patients," said John Halls, managing director of Chugai's European business.

Chugai has had a good quarter when it comes to cancer trials as in February a Phase III trial for its lung cancer drug Alecensa (alectinib) was stopped early as the drug met its primary endpoint and showed that patients were living "significantly longer" with the treatment when compared to Pfizer's ($PFE) marketed drug Xalkori (crizotinib).

Aplidin, a first-in-class drug specifically targeting eEF1A2 in tumor cells, is an investigational anticancer agent of marine origin, originally derived from the Aplidium albicans, a species of sea squirt.

This is not the first time a Japanese company has turned to the depths of the sea for an anticancer treatment. Fellow Tokyo pharma Eisai currently markets Halaven (eribulin) for certain types of breast cancer--a drug created as a synthetic version of a marine sponge.

A full evaluation of the final data from the two companies' study will be presented at an upcoming medical meeting.

- check out the release

Suggested Articles

The FDA has lambasted the Torrent Pharmaceuticals in a warning letter for making OTC meds using water tainted with bacteria.

Novartis' Sandoz doubled down in Japan as Lupin retreated. Dr. Reddy's posted a loss tied to its Zantac recall. Aslan's varlitinib failed again.

The FDA has slapped the parent of Dollar Tree stores with a warning letter saying some CMOs that made its OTC products were among the world's worst.