U.S. patients are racking up big annual drug costs like never before. According to a report from the pharmacy benefits manager Express Scripts ($ESRX), more than a half-million patients in the U.S. had medication costs of more than $50,000 last year, up by 63% from 2013 totals. And the number who used more than $100,000 worth of drugs grew even more--to 139,000 in 2014 from 47,000 in 2013. Report