The market-share gap between next-gen anticoagulants Xarelto and Eliquis has never been smaller--and with a high percentage of patients still turning to old-guard therapy warfarin, it’s anyone’s race.
In its Q3 earnings presentation, Johnson & Johnson rolled out a graph of total prescription share that showed Bristol-Myers Squibb and Pfizer's Eliquis steadily gaining on its own market leader, Xarelto.
The way J&J sees it, there’s still a lot of room out there to grow its blockbuster, because about 54% of patients are still using the older, less-convenient med warfarin, J&J said during its presentation. There's reason for that, J&J acknowledged; unlike warfarin, whose blood-thinning effect is easily countered with vitamin K therapy, the crop of new-age meds--save Boehringer Ingelheim’s third-place Pradaxa--has no reversal agent to stop severe bleeding in an emergency.
But the next-gen drugs have other advantages, and Pfizer and Bristol know those warfarin patients are there for the taking--and the partners aren’t planning to let J&J run away with all the conversions. After getting off to a brutally slow start, Eliquis has picked up the pace on the back of increased marketing spend, and earlier this year BMS claimed it had a future market leader on its hands.
Johnson & Johnson doesn’t sound worried about its rival’s steady rise, though. Its own market share ticked up to 17.5% in Q3, a 1.7-point increase over the same period last year. And the pharma giant still boasts the largest clinical trial program of the group; it’s conducting 10 trials with new indications or label expansions in mind, spanning conditions including heart failure, embolic stroke and coronary artery disease.
Those new line extensions are no small deal, J&J’s worldwide pharmaceuticals chairman, Joaquin Duato, told investors on the company’s Q3 conference call. The extensions for Xarelto--combined with those planned for Type 2 diabetes med Invokana--“have the potential to drive $3 billion to $5 billion in incremental sales for the cardiovascular franchise,” he said.
BMS expects fast-growing Eliquis to take the lead over Xarelto, Pradaxa
Bristol-Myers immunotherapies soar, but Eliquis haul tops the charts
Boehringer looks for Pradaxa boost from now FDA-approved antidote
J&J-Bayer and Pfizer-BMS look for advantages in real-world Xarelto, Eliquis data
How can Pradaxa, Xarelto and Eliquis finally unseat warfarin? Safety data, analyst says
BMS, Pfizer pull out all the stops to give Eliquis sales a Q2 jolt