Express Scripts hobbles new Synergy med Trulance with Allergan-favoring formulary maneuver

Synergy's Trulance launched in March as a treatment for chronic idiopathic constipation.

Earlier this year, Allergan’s Linzess and Takeda’s Amitiza gained a new competitor in Synergy’s Trulance. But just as the newcomer was settling into challenge mode, Express Scripts has dealt it a serious blow.

Just a little more than four months into its launch, the med has received the cold shoulder from Express Scripts, which excluded it from its national preferred formulary for 2018. Instead, the PBM says, it prefers either of the older meds as options for chronic idiopathic constipation, the approval Trulance bears, or IBS-C, an indication Synergy is currently chasing.

RELATED: Synergy's Trulance wins an OK to battle Allergan's Linzess in CIC—and IBS-C could be next


Simplify and Accelerate Drug R&D With the MarkLogic Data Hub Service for Pharma R&D

Researchers are often unable to access the information they need. And, even when data does get consolidated, researchers find it difficult to sift through it all and make sense of it in order to confidently draw the right conclusions and share the right results. Discover how to quickly and easily find, synthesize, and share information—accelerating and improving R&D.

Some analysts liked the $353-per-script price tag Synergy slapped on the newcomer; it matched Linzess’ and came in just a tad above Amitiza’s $350-per-script cost, boding well for “adoption among patients, payers and physicians,” Oppenheimer’s Derek Archila wrote to clients at the time. In May, Synergy said it was already poaching patients from other drugmakers, with about half of scripts at that point going to those who’d been on other branded medications.

Express Scripts, though, may have been looking for a bigger discount, as PBMs are wont to do. Just look at how fellow new launch Tymlos, a bone drug from Radius that undercut its competition, fared: Express Scripts listed it as a preferred med, kicking off fixture Forteo from Eli Lilly to make space.

RELATED: Synergy preps for Trulance launch with competitive pricing, experienced GI reps

Now, it’ll be up to Synergy’s field force of 250 reps to help navigate around the setback. They’re currently targeting a prescriber base of 27,000 gastroenterologists, primary care physicians, nurse practitioners and physician assistants, the company said in May.  

Suggested Articles

The FDA has granted Amarin's Vascepa a possible blockbuster label expansion for CV risk reduction in patients with or without CV disease.

In a high-stakes patent lawsuit between CAR-T companies Bristol-Myers Squibb and Gilead Sciences, BMS has come up with a victory. 

It’s been a year of ups and downs for Pfizer’s Xeljanz. But the company is hoping to close on a high note, with help from a new extended-release pill.