Live from Interphex: Pall reveals single-pass TFF system

NEW YORK - Filtration specialist Pall used Interphex as the launching pad for a single-pass tangential flow filtration product and a filter integrity test instrument.

The Cadence system incorporates a module that uses a patented fluid path design for direct-flow operation, reducing system hold-up volume, says Ian Sellick (pictured), marketing director at Pall. So the system requires no recirculation loop. Users can couple the filtration component with equipment used in subsequent process steps, the company says, yielding a throughput increase.

The TFF design eliminates or reduces the need for intermediate storage tanks, and the requisite cleaning, in applications involving in-process volume reduction. Users can integrate the system into such downstream processes as chromatography and virus removal.

Pall also took the wraps off a filter-integrity test instrument, Flowstar IV. It uses the company's direct-flow measurement technology based on volume dosing, so users don't need to measure upstream filter assembly volume and pressure decay. Tests include forward flow, bubble point, water intrusion, combined forward flow/bubble point, and leak and decay. Forward flow test range is 0.1 to 1,000 mL/min; accuracy is 0.1 mL/min or 3 percent. Water flow accuracy is measured to 0.03 ml/min.

- here's the TFF announcement
- see the instrument release