Eli Lilly, Amgen join forces to scale production of COVID-19 antibody cocktails
Eli Lilly has already appealed to the FDA for an emergency approval for RA med Olumiant as a potential treatment for COVID-19. (Lilly)
Months of fervid research have whittled away most potential options to treat patients with COVID-19, a group of antibody cocktails still hold promise. Eli Lilly believes so strongly in its contender that it's bringing on a major pharma partner to chip in on production.
Eli LIlly and Amgen have teamed up to scale manufacturing of future antibody cocktails, including Lilly's LY-CoV-55, in testing to treat COVID-19, the partners said Thursday.
In a joint statement slim on details, both drugmakers pledged only to "quickly scale up production" of a range of neutralizing antibodies Lilly is studying to treat COVID-19—if any get over the regulatory finish line, that is.
Lifecycle Management Strategies Targeted For Patient Populations with Swallowing Disorders
Hear from industry experts as they discuss life cycle management strategies for patients with swallowing disorders and the overall impact on patient perception. The webinar will include several panel speakers representing different perspectives and case study examples. Save your spot and register today!
The most promising of those candidates is LY-CoV-555, an AbCellera-partnered cocktail that entered phase 3 human testing in August. Lilly is also developing LY-CoV016 through a licensing deal with China’s Junshi Biosciences and has launched a phase 2 trial testing a combination of the two in patients with early, mild to moderate COVID-19.
An Amgen spokesman declined in an email to offer further details on the deal.
So far, Lilly's lead antibody candidate has shown mixed promise in human tests, with data from a phase 2 trial release this week showing two of three tested doses didn't top placebo in reducing patients' viral load at the 11-day mark.
Only the 2,800-milligram dose met the primary endpoint. The other two doses—700 milligrams and 7,000 milligrams—did no better than placebo. Typically, the highest dose of a drug has the biggest effect.