Keyword: Wyeth

Pfizer

9. Pristiq

Pfizer's antidepressant Pristiq hit the market in 2008, just as its predecessor, Effexor, was nearing the end of its branded life. As a "new-and-improved" version of Effexor's active ingredient, venlafaxine, Pristiq was the hoped-for successor to that blockbuster brand, but it never cracked $1 billion in the U.S.