Keyword: Adempas

8. Bayer

Bayer’s 2017 sales may have grown by 1.5% over 2016, but not even the company’s CEO, Werner Baumann, would call it a good year.

10. Remodulin

United Therapeutics was built on Remodulin. The company grew out of a career change for CEO Martine Rothblatt, who built Sirius satellite radio before getting into pharma. Her son’s diagnosis of pulmonary arterial hypertension inspired the move—and Remodulin, which was approved in 2002.