Many drug failures are really drug delivery failures

Many drugs fail in clinical trials not because they do not work, but because they lack a proper delivery mechanism. Pankaj Karande, a Rensselaer Polytechnic Institute assistant professor of chemical and biological engineering, understands this and is trying to solve this delivery problem at its most confounding level--the brain. "You can have the best and most promising of drugs, but if it doesn't go where it is needed, then it won't be effective," Karande says in a profile on RPI's website. "There are a lot of new discoveries within the area of drug development, even related to treatment of Alzheimer's. There is not a drug discovery problem; drug delivery is really the challenge." Karande is working with grants from the Alzheimer's Association to find ways of bypassing the challenging blood-brain barrier to get medicines to their intended targets. Profile