Cancer cells hit with a 'Big Mac' attack

From "Fantastic Voyage" submarines to Trojan Horses, scientists seem to spend as much time coming up with appropriate metaphors for their drug-delivery devices as they do with the actual research. But here's a new one: University of Central Florida graduate student Otto Phanstiel is experimenting with polyamines--molecules that are important growth factors for cells. In colon and pancreatic cancer, polyamines feed off neighboring cells to grow. One solution Phanstiel has come up with is to use the cancer-cell polyamines' natural tendency to want to "eat" and give them toxic drugs, instead. "It's the poison Big Mac approach to cancer therapy," Phanstiel says. "Poison the Big Mac and he who eats the most, dies the fastest." Nice analogy. However, one might argue that he who eats the most Big Macs, even without the poison, dies the fastest. More here

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