AC5(TM) Safety Further Supported by Non-Interaction With Tested Biological Targets
WELLESLEY, MA -- (Marketwired) -- 01/06/15 -- Arch Therapeutics, Inc. (OTCQB: ARTH) ("Arch" or the "Company"), developer of the AC5 Surgical Hemostatic Device™, obtained positive results from preclinical tests in which AC5™ was subjected to a battery of high-throughput in vitro safety assessments for biological interactions in standardized testing panels of receptors on the surface of cells and protein kinase enzymes inside cells. These receptors and enzymes represent important biochemical "switches," and interactions with them could indicate biological activity with the potential for toxicity. AC5 is a unique development-stage hemostasis product being evaluated to control bleeding and fluid loss in order to provide faster and safer surgical and interventional care.
In this in vitro study panel, AC5 tested in relevant amounts had no interactions with the examined 71 individual cell receptors or 211 separate cell kinase enzymes. These outcomes support AC5 as a non-toxic product to biochemical targets. Results from these safety interaction studies indicate that AC5's mechanism of action, which is the formation of a local physical-mechanical barrier, does not rely on AC5's interaction with known human receptors or enzymes to inhibit bleeding and leaking.
Arch Therapeutics President and CEO Terrence Norchi, MD, stated, "These differentiating results provide additional safety experience with AC5. The data highlights that there is no evidence of unintended interactions with the nearly 300 tested targets in the body, and it underscores the straightforward mechanism of action. We believe that AC5 has the potential to be a standout in terms of safety, efficacy and user friendliness."
About Arch Therapeutics, Inc. Arch Therapeutics, Inc. is a medical device company developing a novel approach to stop bleeding (hemostasis) and control leaking (sealant) during surgery and trauma care. Arch is developing products based on an innovative self-assembling peptide technology platform to make surgery and interventional care faster and safer for patients. Arch's flagship development stage product candidate, known as AC5 Surgical Hemostatic Device, is being designed to achieve hemostasis in minimally invasive and open surgical procedures.
Find out more at www.archtherapeutics.com.