Webinar
Beyond Protein Counts: Evaluating Depth, Robustness, and Biological Interpretability in Plasma Proteomics
Human plasma proteomics offers significant potential for biomarker discovery and translational research, but deeper proteome coverage is only part of the challenge. Measurements must also be reproducible, interpretable, and robust to preanalytical variation.
In this webinar, a researcher from Roche will present a direct head-to-head evaluation of six plasma proteomics workflows, including Seer Proteograph XT, P2, Mag-Net, ENRICH-iST, Top14 depletion, and neat plasma analysis.
The study examines how these workflows compare in proteome depth and reproducibility, and how sample preparation and increasingly stringent plasma processing influence the biological origin and stability of measured protein signals.
You will learn about:
- Why proteome depth should be considered alongside reproducibility and biological interpretability
- How cellular and vesicular contributions can affect apparent proteome depth
- Why the secreted plasma proteome remains remarkably stable across processing conditions
- Why evaluating plasma proteomics technologies requires looking beyond protein counts toward the robustness and biological interpretability of the measurements used to support downstream research decisions
Speakers
