Prostvac

Vaccine: Prostvac
Company: Bavarian Nordic
Target: Castration-resistant prostate cancer

Sometimes two are better than one, especially where advanced cancer is concerned. A Phase I study that combined Prostvac, Bavarian Nordic's poxvirus-based investigational therapeutic cancer vaccine, with Bristol-Myers Squibb's ($BMY) Yervoy (ipilimumab) in men with metastatic castration-resistant prostate cancer showed that the combination may enhance the clinical efficacy of the two drugs. Yervoy is already approved for the treatment of melanoma, and Prostvac is in a global Phase III trial, known as PROSPECT, which began in November 2011.

In the study, men received increasing doses of ipilimumab and fixed doses of Prostvac. This was a small and non-randomized study, but even so, the combination produced a median overall survival of 34.4 months, an 8.5-month improvement, along with decreases in levels of prostate-specific antigen (PSA), a prostate cancer biomarker. Some of these reductions were more than 50%.

The results are intriguing and could hint toward the efficacy of combined therapies--a study under way with the Cancer Institute of New Jersey (CINJ) and the National Cancer Institute is looking at combining Prostvac with flutamide, a standard hormone therapy for prostate cancer, to see if adding the two together will help in hormone-resistant cancer.

In another combination approach, adding Prostvac to a radiopharmaceutical, Quadramet (samarium-153 EDTMP) in patients with metastatic castration-resistant prostate cancer, was well-tolerated, with early signs of an increase in the time to tumor progression.

Prostvac
Read more on

Suggested Articles

GSK expects Shingrix supplies to rise slightly in 2020, but the real "step change" will come in 2024 with a brand-new manufacturing facility.

Ebola has claimed thousands of lives in recent outbreaks, but now the world has a licensed vaccine option in Merck's Ervebo.

Cosette Pharmaceuticals which was formed in December with a deal for dermatology projects has gone back to G&W Labs for a liquids plant.