GlaxoSmithKline

Total: $59.1 million

Top drug
Advair (COPD): $47.7 million
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GlaxoSmithKline ($GSK) put its advertising dollars to work generating sales of asthma treatment Advair. It was its top-selling drug at $7.7 billion last year, making up about 20% of the company's sales. The respiratory drug actually went off patent in 2010, but its Diskus inhaler is so difficult to copy that no generics have challenged it and none are on the horizon. That is despite an FDA decision to limit the clinical testing required for approval. Teva Pharmaceutical Industries ($TEVA), the largest generic drugmaker in the world, said that even with the new ground rules, it doesn't expect to see true substitutes for the GSK best-seller before 2018. U.S. sales of Advair in the first 6 months of the year were up 5% to $3.6 billion.

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