Back in 2008, MonoSol ($MSRX) and Midatech teamed up to develop PharmFilm, a through-the-cheek nanoparticle-delivery platform they eventually patented in 2010. Now, the duo is developing an insulin-delivery application for the transbuccal tech. PharmFilm is a quick-dissolve mucoadhesive film, sticking to the inside of the cheek and delivering APIs. Loading the film with insulin presents a lucrative opportunity, the companies figure, and the diabetes-treating formulation got some positive results in Phase I. The bioavailability and pharmacokinetics were all up to snuff, and the stamp-sized strips worked faster than subcutaneous insulin, the companies said. MonoSol and Midatech haven't disclosed a planned timeline for the tech, but they've got more human trials on the horizon.
3. Oral insulin film from MonoSol and Midatech
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