Peptide Vaccine Stimulates Immune Response in Patients With Breast Cancer
April 2, 2012
- Patients with breast cancer responded well to vaccine for recurrence prevention.
- T regulatory cells decreased in patients assigned to the vaccine.
- Immunologic testing may help identify responders to peptide vaccine.
CHICAGO — Patients with breast cancer assigned to the HER2-based peptide vaccine AE37 had immunologic responses compared with a control group, according to 24-month results presented at the AACR Annual Meeting 2012, held here March 31 - April 4.
"The theory is that once you form that response to the specific peptide, if the body has a recurrence, it will recognize that cancer as a bad thing, a foreign thing," said Diane F. Hale, M.D., a research resident in general surgery at Brooke Army Medical Center in Fort Sam, Houston, Texas. "The immune markers could lead us to potentially identify those people who may have a recurrence."
Of the 217 women enrolled in this prospective, randomized, single-blinded phase II trial, all had completed the standard therapy for breast cancer and were disease-free at the start of the trial.
"We wanted the high-risk patients, those who are at the highest risk for recurrence, so we included those patients who were node-positive or who were node-negative but had poor prognostic factors, such as ER/PR negativity," Hale said.
Researchers assigned 109 patients to AE37 and the immunoadjuvant granulocyte-macrophage colony-stimulating factor (GM-CSF) and assigned 108 patients to GM-CSF alone in six monthly intradermal injections.
They evaluated in vivo delayed-type hypersensitivity reactions by injecting a small, nontherapeutic dose of the vaccine beneath the patient's skin and looking for a physical reaction of greater than 5 mm. In the vaccine group, 86 percent of patients showed a significant response compared with 27 percent of patients in the control group.
In addition, researchers evaluated in vitro proliferation responses and found that the vaccine group had more responders than the control group. The latter group had more nonresponders, based on stimulation indexes.
"Naturally, the people in the vaccine group had a significant response compared with the control group because they didn't have that immune stimulation to the HER2 peptide," Hale said.
Researchers also measured T regulatory cell responses in 107 patients. Within the vaccine group, "there was a larger percentage of patients who had a decrease in their T regulatory cells" from prevaccination baseline, Hale said. Forty-one patients assigned to the peptide vaccine vs. 28 patient controls had a decrease of more than 90 percent.
Monitoring immunologic tests and T regulatory cells throughout the vaccination process may classify patients as responders and nonresponders. "That can also help us in the future to identify who may recur," Hale said.
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About the AACR
Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR's membership includes 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 18,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the Scientific Partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of individual and team science grants in cancer research that have the potential for patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.
For more information about the AACR, visit www.AACR.org.
In Chicago, March 31 - April 4: