Nanoparticles made from grapefruit lipids deliver drugs safely

Using lipids derived from grapefruits, researchers at the University of Louisville have created nanoparticles for drug delivery that are less toxic to both people and the environment and may offer a less expensive alternative to synthetic materials. The grapefruit-derived nanovectors can carry various therapeutic agents, DNA, RNA and proteins such as antibodies, as shown by the researchers in a paper in Nature Communications, and are currently undergoing a Phase I clinical trial to treat colon cancer with oral delivery. The scientists also hope to use the nanoparticles to treat autoimmune diseases like rheumatoid arthritis. Article | story