A team of Japanese researchers has developed a dissolving microneedle delivery system. The chip, with 225-300 insulin-loaded microneedles, is pressed into the skin, delivering the insulin transdermally. In a preclinical study, it successfully reduced blood glucose in rats, with the amount dependent on how far the microneedles were pressed into the skin, and how long they remained in place. According to the researchers, the "results suggest the usefulness of the two-layered DM [dissolving microneedles] application system for the transdermal delivery of insulin." Abstract