Spotlight On... Takeda bails on obesity med Contrave, spelling trouble for maker Orexigen; Vectura inks all-stock pact for SkyePharma; Allergan launches Vraylar in the U.S.; and more...

Amid underperforming sales and an expensive outcomes trial tab, Takeda is walking away from its marketing pact with Orexigen ($OREX) for obesity therapy Contrave. Now, it'll be up to Orexigen to compete in the U.S. without the Japanese pharma's 900 reps, who helped it grab a leading slice of the pie despite third-to-market entry. But in the meantime, Orexigen is also on the hook for a cardiovascular outcomes trial that could cost up to $250 million--a tall order for the California drugmaker, which netted just $53 million in Contrave sales last year. More from FiercePharmaMarketing

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> Respiratory drugmaker Vectura has agreed to buy SkyePharma in an all-stock deal that values the drugmaker at $621.9 million. Report

> Allergan ($AGN) has launched antipsychotic Vraylar in the U.S. Release

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> The journal Vaccine has yanked a "seriously flawed" and "unjustified" study that purported to find new side effects to Merck's ($MRK) HPV shot Gardasil. Report

> Bayer is setting up an East Coast innovation hub in Cambridge, MA, joining a wide array of biopharma companies looking to take advantage of the institutions and expertise there. Report

Medical Device News

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Biotech News

@FierceBiotech: MIT team demonstrates potential of cancer combo for kinase inhibitors in mice. More from FierceBiotechResearch | Follow @FierceBiotech

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> Bayer plots a dealmaking hub in the biotech boomtown of Cambridge, MA. Report

> Vectura lands $621M merger deal with SkyePharma. Story

> Takeda and Frazier back a $41M round for a new urology biotech. Article

Pharma Marketing News

> GlaxoSmithKline's nicotine franchise pairs up with smoking cessation app. Report

> Good news, hep C drugmakers: VA stops rationing your pricey treatments. More

> Getting serious about digital: Takeda walks the walk with its digital accelerator model. Story

> Takeda dumps weight loss med Contrave, leaving Orexigen in the lurch. Article

Biotech Research News

> Novartis-allied scientist at Penn creates a new CAR-T model for solid tumors. More

> HDAC/PI3K inhibitors could treat common childhood cancer. Report

> MIT team demonstrates potential of cancer combo for kinase inhibitors in mice. Story

> New insights into Parkinson's disease. Item

> HIV drug increases therapeutic window for skin cancer by slowing drug resistance. Article

Vaccines News

> Journal walks back 'seriously flawed' study critical of Merck's Gardasil. More

> Analyst: Mitsubishi Tanabe's tobacco-based flu jab could have 'significant impact' on market. Story

> Health agencies inform on Zika vaccine timeline. Report

> Valneva scores $42M supply contract with DOD. News

> Duke, NIAID track HIV evolution with eyes on creating a vaccine. Article

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