Shire stands to suffer from Genzyme plant OK; Krka's 2011 sales break €1B;

@FiercePharma: Interesting executive interview/analysis of Cipla's management tweaks, efforts to jump start exports--ET. Article | Follow @FiercePharma

> Shire ($SHPGY) faces 'significant headwinds' now that Fabry disease drug rival Genzyme has won European approval for its new Boston-area plant, an analyst said. Story

> Watson Pharmaceuticals ($WPI) launched Vestura, its generic version of Bayer's oral contraceptive Yaz. Item

> Slovenian drugmaker Krka said 2011 sales rose 6% to top €1 billion. Report

> New Irish guidelines for pharmaceuticals marketing prohibit entertaining health professionals at sporting and entertainment events. Story

> Contract manufacturer and API maker AMRI ($AMRI) won U.K. approval for its plant in Holywell, Wales, on top of a successful FDA audit last June. Article

> Brazil introduced Sanofi Pasteur's injectable polio vaccine into its national immunization program, which also includes doses of an oral polio vaccine. News

> Indian generics maker Sohm said its new nutraceuticals plant in Ahmedabad has started turning out its new line of remedies, including a probiotic anti-diarrheal, Diorac. Report

Biotech News

@FierceBiotech: Scientists balk as U.S. gov't pushes limits to bird #flu discourse. Article | Follow @FierceBiotech

@JohnCFierce: Just about everybody expected dapagliflozin to get batted down; but the rejection also spells trouble for other SGLT2 inhibitors. | Follow @JohnCFierce

@RyanMFierce: Hmm. Is it realistic for Obama to set a 2025 goal for effective ways to treat and prevent Alzheimer's? More | Follow @RyanMFierce

@FierceMedDev: Covidien gives update on voluntary recall of BIS bilateral sensors. Release | Follow @FierceMedDev

> FDA rejects dapagliflozin for diabetes, raising concerns for a class. Story

> Bristol-Myers reports interferon-free cures in small PhII hep C study. Article

Vaccines News

> Novartis' meningitis B vaccine aces study en route to market. News

> Breast cancer vaccine set for large-scale testing. Story

> Flu season gets off to a sluggish start. More

> Paragon nabs $15M filovirus vax contract from DoD. Item

> Confident Inovio chief pushes ahead on universal flu vaccine. Article

Pharma Manufacturing News

> Bioprocess budget hikes a sign of efficiency quest. Report

> Genzyme revives Fabrazyme with EMA plant OK. News

> Congresswoman: Novartis troubles call for more FDA oversight. Item

> Novartis, Lundbeck score wins for manufacturing in the West. Article

And Finally... Dementia patients in nursing homes who use antidepressants are more likely to fall, a new study found. Report