Research and Markets: Ophthalmology Drug Futures

DUBLIN--(BUSINESS WIRE)-- Research and Markets ( has announced the addition of the "Ophthalmology Drug Futures" report to their offering.

Ophthalmology Drug Futures: An expanding market with high unmet clinical need and huge commercial opportunity

A complete and practical analysis of Ophthalmology Drugs packed with facts, figures and forecasts for launched and late-stage products

The US$14 billion global ophthalmology sector faces both commercial challenge and clinical opportunity, and this report answers key questions:

  • Why are we interested in chronic eye diseases?
  • Driven by ageing populations, which markets are expected to see the highest growth in the 65+ age groups?
  • Which sectors of the market are anticipated to contract by value over the next five years?
  • What new products will be launched over the next 5 years and what impact will they have on the market?
  • Which companies are set to improve their market share?
  • What novel products are in development for Wet Age-related Macular Degeneration (AMD)?
  • Dry AMD - large unmet clinical need, but what is the potential?
  • What potential benefits does Bayer's VEGF Trap-Eye Regeneron have over existing treatments?
  • Merck's NDA for Saflutan was submitted to FDA in March 2011 - what impact on the market could this product have?
  • Why are new treatments needed for dry eye?
  • Sight preservation in chronic eye disease is a high yielding, valuable and expanding sector in developed and emerging markets


The market for drugs used to treat wet age-related macular degeneration (AMD) is estimated to be worth US$3.3 billion. There are relatively few players and an increasing patient pool; continued growth is expected over the medium term.

The current standard of care for wet AMD is Lucentis (ranibizumab), marketed by Roche in the US and Novartis elsewhere. Growth has been impressive since its launch in 2006; global sales amounted to US$3 billion in 2010. The cost of treatment is high, however, and there is some competition from off-label use of Roche's Avastin (bevacizumab), which is significantly cheaper. In the US, the National Eye Institute is conducting a major Phase III comparative study of Avastin and Lucentis for the treatment of AMD.

GLAUCOMA Glaucoma affects around 65-70 million people worldwide and is the second leading cause of blindness, after cataracts. The WHO estimates that glaucoma was responsible for around 12.3% of world blindness in 2002, affecting around five million people.

Undoubtedly, generic companies will claim a significant share of the US$4.9 billion glaucoma market over the next few years. Pfizer's US patent for the market leader, Xalatan (latanoprost) expired in March 2011 and the first generics have been approved. Others in this segment are also set to lose exclusivity over the next few years. Dependent on the outcome of patent litigation, Alcon's Travatan Z (travoprost) could face generic competition in the US as early as December 2011. Allergan's US patents for Lumigan (bimatoprost) will expire in 2012 and 2014, while the European patents are set to expire in various markets between 2013 and 2017. DRY EYE SYNDROME

Alongside glaucoma and AMD, dry eye is a growing problem and one that also increases with age. While this condition is widely treated with artificial tear products that are available over the counter, the prescription market is currently worth around US$1.5 billion.

There are relatively few prescription pharmaceuticals to treat more severe cases; in the US, Allergan's Restasis (ciclosporin) ophthalmic emulsion is currently the only product approved to increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation. Competition may be on the horizon, however, from ISTA Pharmaceuticals' Remura (bromfenac), which is in Phase III for the condition.

To view the reports full table of contents and for more information visit

Source: Espicom Business Intelligence Ltd


Research and Markets
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INDUSTRY KEYWORDS:   Health  Optical  Pharmaceutical