Pfizer to shutter or sell Irish plant that employs 136; Bayer launches Stivarga trial in liver cancer;

@FiercePharma: ICYMI - execs' bogeymen: Animal-rights extremists, disease activists and laid-off workers, security tells FAA. Report | Follow @FiercePharma

> Pfizer ($PFE) will close a plant in Little Island, Ireland, planning to consolidate its operations with another plant in nearby Ringaskiddy; the shutdown will affect 136 employees there, Irish media report, unless Pfizer can find a buyer for the facility. Report

> Bayer started a new, late-stage trial of its potential blockbuster treatment Stivarga, in patients with advanced liver cancer. Report

> The FDA approved new labeling for common insomnia drugs, including Sanofi's ($SNY) Ambien, that caution patients from driving or taking part in other activities that require alertness the next day, and recommend lower doses to minimize side effects. Report

> The FDA said it would review an application for broader use of Seattle Genetics' ($SGEN) lymphoma drug Adcetris. Report

> Biotech drug sales in Germany leapt 11% in 2012, compared with a 2.4% increase in drug spending on the whole, an industry association said. Report

Medical Device News

@FierceMedDev: Elixir snags CE mark for dissolvable stent. News | Follow @FierceMedDev

@MarkHFierce: Roche won crucial FDA approval for a companion diagnostic for lung cancer. Goes with Astellas' Tarceva. Release | Follow @MarkHFierce

 @DamianFierce: Analogic is lopping off 140 jobs in Colorado and Vancouver. More | Follow @DamianFierce

> Daktari Diagnostics reels in $7M as it preps for Scotland expansion. Story

> Vermillion private placement comes through. Item

Biotech News

@FierceBiotech: $VVUS announces proposed offering of convertible senior notes. Release | Follow @FierceBiotech

@JohnCFierce: Quintiles joins Merck KGaA's R&D command post in 5-year exclusive. News | Follow @JohnCFierce

@RyanMFierce: Billionaires back Kite Pharma in $20M raise for cancer immunotherapies. Article | Follow @RyanMFierce

> FDA OKs pinpoint prostate cancer radiation drug Xofigo from Bayer, Algeta. News

> New crowdfunding platform set to launch new biotechs. More

> Tokai lands $35M venture round for triple-threat prostate cancer drug. News

Drug Delivery News

@MichaelGFierce: Israeli team spurs nerve healing with implant-released gel. More | Follow @MichaelGFierce

> New polymers shatter to release drugs at specific target. Report

> Marina platform to deliver first-ever miRNA cancer drug for Mirna PhI. News

> Scripps study reveals new RNA-drug targeting potential. Article

> FDA accepts Merck's sublingual allergy med license application. Item

Biomarkers News

> Genome mutations reveal acute myeloid leukemia risk, potential drug targets. Story

> Biomarker trio enables blood Dx to map heart attack risk. More

> Bristol-Myers Squibb, Adaptive Biotechnologies ally for cancer biomarker development. More

> Fetus secretes hormone that could flag preeclampsia risk. Article

> 9 blood-based biomarkers correspond to amyloid plaque in the brain. Item

And Finally... Two in-vitro patties and special sauce on a bun? Researchers say engineered beef is on its way. Report

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Despite a veritable graveyard of drug prospects in hard-to-treat glioblastoma, Bayer hopes underperforming Stivarga can crack the code in new trials.