Obama back on campaign trail for reform; Amgen plots $1 billion senior note sale;

  @FiercePharma: GSK, Merck promise more deal-making. Article | Follow @FiercePharma

> President Barack Obama made a spirited, shirt-sleeved appeal for passage of long-stalled healthcare changes as Democratic leaders worked behind the scenes on legislation they hope can quickly gain passage. Report

> Amgen plans to sell $1 billion of senior notes in a two-part sale, reports IFR, a Thomson Reuters service. Report

> Matrixx Initiatives says the FDA declined to withdraw the warning letter on the company's nasal versions of Zicam cold remedy. Report

> Stirling Pharma, an Australian group, has taken over North Sydney-based Keata Pharma for about $3.6 million. Report

> Watson Pharmaceuticals asked FDA to approve its version of a painkiller made by Endo Pharmaceuticals, prompting a patent suit from Endo and partner Penwest Pharmaceuticals. Report

> Regular use of pain-relief medicine appears to increase men's risk of hearing loss, especially those who are middle-aged. Report

Biotech News

   @FierceBiotech Between 4Q07 and 4Q09, 25 percent of US public biotechs disappeared (half via M&A), says BIO. | Follow @FierceBiotech

  @JohnCFierce: For sale: Ark Therapeutics. Willing to consider any serious offer. Buyer must be willing to mount new Ph3 for lead drug. Follow @JohnCFierce

> AutoImmune calls it quits. Item

> With Astellas Pharma and OSI Pharmaceuticals haggling over price, BNet Pharma wonders which biotechs could be next on the buyout menu. Story

> InterMune trading halted on panel review. Article

> The emphasis in the European biopharma scene is squarely on finding a new equation for drug discovery that relies less on internal R&D operations and more on external drug discovery work. Report

> Ark in sales talks after regulators demand new trial. Story

> South San Francisco-based Exelixis is axing 270 jobs--40 percent of its workforce--as it circles its wagons around its top three cancer programs. Article

Manufacturing News

> Labels deal supports drug authentication. News

> Indian API maker Aurobindo Pharma has become the latest scrambler for the manufacturing services bounty expected from a morphing drug industry model. Item

> The 230,000-square foot Ann Arbor facility closed by Pfizer in 2008, following a $250-million expansion six years earlier, is being scrutinized by owner University of Michigan. Report

Biotech Research News

> In the Journal of Clinical Investigation, Yale School of Medicine researchers say they've discovered a way to grow coronary arteries that could eventually lead to a non-invasive option for conducting heart bypasses. Item

> U of M researchers discover HIV reservoir. Story

> Danish scientists have determined sufficient intake of vitamin D is vital for the killer T cells of the immune system to fend off serious infections. News

And Finally... Doctors and hospitals are getting a new test that many think will help fight ovarian cancer--one of the deadliest cancers--by helping them to more quickly distinguish cancerous from benign growths. Report

Virtual Clinical Trials Summit

Virtual Clinical Trials Summit: The Premier Educational Event Focused on Decentralized Clinical Trials

In this virtual environment, we will look at current and future trends for ongoing virtual trials, diving into the many ways companies can improve patient engagement and trial behavior to enhance retention with a focus on emerging technology and harmonized data access across the clinical trial system.