Novartis's Afinitor flunks breast cancer trial; Supreme Court stays mum on Teva appeal;

@FiercePharma: AbbVie CEO's pay doubles to $18.2M in Abbott pharma spinoff's first solo year. More | Follow @FiercePharma

@TracyStaton: Top-read at FiercePharma: Tokyo hospital exec says Novartis employees deeply involved in leukemia-drug trial. Report | Follow @TracyStaton

@EricPFierce: AmerisourceBergen global expansion continues with $100M deal for a 20% stake in Brazil's Profarma. News | Follow @EricPFierce

@CarlyHFierce: Sanofi reportedly jumps into $12B race for Merck's consumer unit. Story | Follow @CarlyHFierce

>Novartis' ($NVS) breast cancer drug Afinitor missed a secondary endpoint of overall survival in a clinical trial that tested the drug in combination with Pfizer's ($PFE) treatment Aromasin. More

> The Supreme Court once again did not announce whether it would hear Teva's ($TEVA) appeal to reinstate 2015 patents on its multiple sclerosis drug Copaxone. Report

> Pharma wholesaler AmerisourceBergen ($ABC) will invest about $100 million for a minority stake in Brazilian drug distributor Profarma Distribuidora de Produtos Farmacêuticos S.A. More

> IMS Health expects to price its IPO at $18 to $21 per share, valuing the company at up to $6.97 billion. Report

> Bayer was unable to get a tolling ruling nixed in a $100 million sex discrimination suit. More (sub. req.)

> Glenmark Pharmaceuticals has received $4 million as a drug development research fee from Forest Labs ($FRX), bringing the total to $15 million so far from the New York-based company. Story

Medical Device News

@FierceMedDev: The Axonics CEO told FMD that $32.6M in Series A financing took 3 months. "We did not shop the deal," he said. More | Follow @FierceMedDev

@MarkHFierce: Who is the top med tech company in terms of revenue? Report | Follow @MarkHFierce

@MichaelGFierce: ICYMI: Alexza secures $45 million from investors based on U.S. Adasuve sales. Item from FierceDrugDelivery | Follow @MichaelGFierce

@EmilyWFierce: Israeli medical devicemaker Brainsway developed a helmet to treat depression, sees a leap in revenue. Article | Follow @EmilyWFierce

> Stryker finalizes $120M deal with surgical sponge outfit. News

> NeuroPace's neurostimulation epilepsy implant is already making an impact. Item

Biotech News

@FierceBiotech: FDA review slams Novartis's case for beleaguered heart drug serelaxin. More | Follow @FierceBiotech

@JohnCFierce: This is going to be another one of those weak Q1s for biotech VC. I guess the venture crowd is too busy skiing. Summer should be good, though. | Follow @JohnCFierce

@DamianFierce: Biogen cozies up to MIT with a $5.3M drug discovery pact. News | Follow @DamianFierce

@EmilyMFierce: Another gene linked to obesity. Story | Follow @EmilyMFierce

> Merck's new PhIII hep C program may help repair a damaged R&D rep. News

> Seattle startup sets out with $5M, beer molecules and a plan to treat diabetes. Article

Biotech Research News

> Public-private Japanese partnership invests $15M in infectious diseases. Story

> Mushroom-derived compound could stamp out HPV infection. More

> Antianxiety drugs lessen autism symptoms in mice. Item

> Amylin diabetes drug improves learning, memory in Alzheimer's mice. News

> Technique converts stem cells to muscle cells in high volumes. Report

> Knocking out gene reduces fat, extends lifespan in mice. Article

Pharma Manufacturing News

> India cracks down on same Wockhardt plants FDA has banned. More

> GSK adopts Formula One racing mentality to speed Breo inhaler production. Story

> AMRI ratchets manufacturing up further with Cedarburg buyout. News

> FDA approves J&J to make bulk Doxil at closed Ben Venue plant. Report

> Hospira CEO gets nearly $10M for steering drugmaker through issues. Article

> AmerisourceBergen expands in Brazil with $100M deal. Item

And Finally... Marijuana can help ease certain MS symptoms in ways other alternative remedies can't, according to a report by U.S. neurologists. More