NICE blesses Pradaxa for stroke prevention; Pharma cuts sales and marketing spending 3.4%;

@FiercePharma: Foreign drugmakers may be disgruntled with India's policies, but the market is too big to ignore, the ET says. Article | Follow @FiercePharma

> The U.K.'s cost-effectiveness agency recommended Boehringer Ingelheim's anticoagulant drug Pradaxa for stroke prevention, a key endorsement as the company competes with other new-generation warfarin alternatives. News

> Pharma's worldwide spending on sales and marketing dropped 3.4% last year as companies cut back in established markets such as the U.S. and Europe but increased spending in emerging markets. More

> Canada's Apotex is suing the U.S. government for $520 million, saying an FDA import alert that kept its products out of the U.S. violates the North American Free Trade Agreement. Report

> United Therapeutics sued Sandoz, the Novartis ($NVS) generics unit, over its move to sell a copy of the pulmonary hypertension treatment Remodulin. News

> In perhaps the longest-running potential buyout ever, minority shareholders cite improved performance at Taro Pharma as justification for a higher bid from Sun Pharmaceutical, but Sun refuses. Story

> InterMune said German officials recognized the additional benefit of its pulmonary fibrosis drug Esbriet, a key step toward negotiating a price for the drug under the country's new system. Report

> Cipla Medpro South Africa said regulatory problems, including slow approval of generics and lower-than-expected HIV-drug business, weighed on its sales and shares. Article

Biotech News

@FierceBiotech: Shire ($SHPGY) nabs Bay Area's FerroKin, orphan drug in $325M buyout. News | Follow @FierceBiotech

@JohnCFierce: Merck offers $90M to bankroll new drug discovery institute in San Diego. Article | Follow @JohnCFierce

@RyanMFierce: Stanford developed an algorithm that offers a smarter way to analyze adverse drug reaction data. More | Follow @RyanMFierce

@FierceMedDev: ARM looks to refrigerators, medical devices with new chip, via CNET. Article | Follow @FierceMedDev

> Biogen Idec strikes $34M option pact with MAKScientific. Item

> Sofinnova preps Irish venture plans with $37.5M in fresh support. Story

> Did Big Pharma scuttle an attempt to radically restructure the approval pathway? More

Manufacturing News

> Pfizer's new U.K. cold storage facility has hot new vaccines line. Article

> Industry stymies effort to make it fund drug disposal program. Piece

> J&J's Weldon to get $143M in retirement. Item

> Sanofi cuts continue with closing of manufacturing plant in U.K. More

CRO News

> NeuroNEXT adds med schools to its national CNS clinical trial network. Story

> Indian CROs accuse 'Dateline' of smearing their reputations. Article

> Big quarterly loss whacks ex-Biogen chief's CMO amid transition. More

> Animal rights activists fighting one of the last supply routes for U.K. researchers. Item

> Devicemakers eye outsourcing to limit hit from Obama tax. News

Vaccines News

> Hep C vaccine heads into further clinical trials. More

> GeoVax steps closer to HIV prevention. Story

> In the clinic, Inovio's HIV vaccine treats as well as prevents. Article

> Could a vaccine crack cocaine abuse? Item

> Hand, foot and mouth vaccine triggers 100% immune response. Story

And Finally... A pain-relieving Amazonian plant is now being studied for use at the dentist's office. Report

Virtual Clinical Trials Summit

Virtual Clinical Trials Summit: The Premier Educational Event Focused on Decentralized Clinical Trials

In this virtual environment, we will look at current and future trends for ongoing virtual trials, diving into the many ways companies can improve patient engagement and trial behavior to enhance retention with a focus on emerging technology and harmonized data access across the clinical trial system.