J&J asks FDA to bless important new Xarelto use; Lundbeck sees big drop in antidepressant sales;

 @FiercePharma: Watchdogs at IOM say FDA should be more vigilant on post-marketing safety. Plus, its safety communications are muddled. Article | Follow @FiercePharma

> Johnson & Johnson ($JNJ) asked the FDA to expand use of its anticoagulant Xarelto to treat patients with acute coronary syndrome--a major potential market--and to treat serious blood clots in the legs and lungs. Report

> Lundbeck suffered a larger-than-expected decline in sales of its Cipralex/Lexapro antidepressant to generic competition, but it stuck to its 2012 forecast on the expected strength of new meds. News

> Allergan ($AGN) reported a 10% increase in quarterly sales, to $1.37 billion, and an 11.7% rise in profits, but still fell short of analyst expectations. Story

> ViroPharma's first-quarter results missed estimates after its Vancocin antibiotic sales succumbed to generic rivals and its new Cinryze treatment faltered. More

> Impax Laboratories enjoyed an 18% increase in sales, thanks to a leap forward for its generic Adderall. Item

Biotech News

 @FierceBiotech: Genomics tops chart of social media buzz in biotech IT. Story | Follow @FierceBiotech

 @JohnCFierce: Any promising biotech with a late-stage asset looking to do a deal in the $1B-$5B arena is positioned just right. More | Follow @JohnCFierce

 @RyanMFierce: Lots of activity in developing weight drugs that target brown fat. Roche, Eli Lilly, and two biotech startups are in the hunt. Article | Follow @RyanMFierce

 @MarkHFierce: Pancreatic cancer cases often have a "brake gene" turned off, U.K. scientists found, that lets the tumors spread. Story | Follow @MarkHFierce

> Lilly invests £5.4M in R&D hub in U.K. News

> Lundbeck banks on pipeline as antidepressant sales skid. Item

> Pfizer scouts for bite-sized buyouts after Lipitor sales wilt. Report

> Aveo Pharma flunks Phase II lung cancer study. Story

Medical Devices News

 @FierceMedDev: Study: Doctors use device and drug trials of spotty quality. Story | Follow @FierceMedDev

> Thoratec earnings soar, fueled by HeartMate II LVAD sales surge. News

> Covidien closes $108M bid for Newport Medical. More

> Dentsply sees Q1 profit drop, sales jump. Article

Biomarkers News

> Scans for autism gene groups could open door to genetic biomarkers. More

> Pancreatic cancer protein biomarker could predict outcomes. Item

> Epigenetics signal possible breast cancer blood test. Story

> Weight loss cuts inflammation, cancer markers. Article

Drug Delivery News

 @DamianFierce: Ever wonder exactly how wireless drug delivery works? Well, wonder no longer. News | Follow @DamianFierce

> Swedish discovery could be key to better transdermal delivery. Article

> Researchers develop 'smart' nanostructures for drug delivery. Story

> Genericsmaker banking on novel delivery to raise funds. Item

> Aptar launches new inhaler with eye on emerging markets. News

And Finally... How much and where dopamine is released in the brain may make the difference between slackers and achievers. Report