Germans hold hard line on drug prices; U.K. pricing moves to be unveiled this week;

@FiercePharma: Monday's top special report: Top 10 Drug Patent Losses 2014. Report | Follow @FiercePharma

@CarlyHFierce: ICYMI: J&J to pay $2.2B to wrap up longstanding Risperdal marketing probe. Story | Follow @CarlyHFierce

> German politicians agreed to continue reining in drug spending, with a mandatory discount of 7% fixed for the long term; previously, the discount was set to decline to 6% at year's end. Item

> U.K. officials are expected to announce long-awaited details of the new drug-pricing system set to take effect next year. News

> Spanish pharma company Grifols posted a 35% increase in 9-month net profit, aided by growth in U.S. sales. Report

> German blood plasma products company Biotest is under investigation by German prosecutors for alleged bribery in Russia. Report

> Biotech investments helped boost BlackRock's U.S. Opportunities fund to 29.4% growth over the past year. Story

Medical Device News

@FierceMedDev: Edwards' recall gets FDA's 'deadly' label as problems pile up. Story | Follow @FierceMedDev

@MarkHFierce: CardioDx set the terms for its IPO, upping the range. More | Follow @MarkHFierce

@MichaelGFierce: ICYMI: Langer lab makes synthetic 'good cholesterol' for cardiovascular drug delivery. More from FierceDrugDelivery | Follow @MichaelGFierce

> Infraredx raises more cash to back imaging system ramp-up. Story

> Medtronic, Boston Scientific unleash patent fight at Supreme Court. More

Biotech News

@FierceBiotech: ImmunoGen scuttles lead PhII armed-antibody trial after tracking infection risk. More | Follow @FierceBiotech

@JohnCFierce: Novartis chopping 371 research jobs in global R&D reorganization. Goodbye, Horsham. Article | Follow @JohnCFierce

@DamianFierce: EW's long-running misfortunes continue with a Class I recall of a bypass device. Story | Follow @DamianFierce

> Midatech bags $16M round to back PhIIa studies on oral insulin program. More

> Analyst lays out 'doomsday scenario' for federal probe of AstraZeneca's Brilinta. Story

> Keryx jumps as kidney drug impresses in PhII, promises wider label. Article

Pharma Manufacturing News

> Merck to give pink slips to 500 West Point workers this holiday season. More

> PwC warns quality failings could slow growth of Indian biopharma. Story

> Developer pitches plan for Boston R&D and manufacturing complex. News

> Stalling biosimilars give Roche confidence to reopen Genentech plant. Report

> Novartis puts OTC unit and its troubled plant on second tier of sale priorities. Item

> FDA outlines plan to incentivize high-quality manufacturing. Article

Biotech Research News

@EmilyMFierce: Fewer NIH grants affected by sequestration than initially projected. Item | Follow @EmilyMFierce

> Survey details impact of federal cuts, sequestration on scientific research. More

> Key HIV protein structure revealed. Story

> Prana compound restores learning, memory loss in mice. Article

> Sage molecule could treat a wide range of CNS disorders. Report

> Study: Genetics drive neurocognitive decline in aging. More

And Finally... Animals are increasingly used to help patients with mental disorders from autism to PTSD. Report (sub. req.)

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