AZ to downsize by 135 at MA plant; Pfizer plans $21M upgrade at Michigan plant;

 @FiercePharma: The 12 greenest companies in biopharma. Report | Follow @FiercePharma

> AstraZeneca says it will cut around 135 positions at its manufacturing facility in Westborough, MA, from the end of this month, as part of a previously announced global restructuring. News

> Pfizer has announced another upgrade of its sterile injectables plant in Portage, Michigan, earmarking around $21 million for new air handling, sterilisation and utility systems. Report

> GlaxoSmithKline launched its new anti-epilepsy drug Trobalt in the UK, where it will compete with existing meds such as Pfizer's Lyrica and UCB's Keppra. Item

> Glenmark Pharmaceuticals' U.S. unit settled a patent dispute with Triax Pharmaceuticals and Astellas Pharma, with a deal that will allow it to sell a generic version of Locoid Lipocream, provided it pays royalties on sales through 2013. Item

> A surgeon at Stanford University, in a study released this week, suggests that one of Medtronic's best-selling spinal products poses a risk of male sterility. Story

> British pharma BTG posted a 13 percent rise in full-year revenue, helped by a £6 million ($10 million) contribution from its Biocompatibles acquisition. Report

> Chemicals which enter the environment in the wastewater of pharmaceutical facilities can be taken up by crops and other plant species and are a "real concern," according to researchers in China and the U.S. Article

Biotech News

@FierceBiotech: Successes, failures mark 30 years of HIV/AIDS research. Feature | Follow @FierceBiotech

@JohnCFierce: Novartis racks up more positive Ph3 data on Ilaris and analysts seem bullish about the mab's blockbuster chances. Article | Follow @JohnCFierce

> Pfizer investigator questions cause of deaths in tofacitinib trial. Item

> Novartis gins promising data for late-stage gout drug. Story

> Roche, GSK melanoma drugs in ASCO's "hottest" spotlight. News

Drug Delivery News

> Low-level electrical current delivers long-lasting drugs in the eye. Piece

> Phosphagenics, 3M a step closer to oxycodone patch. Item

> PolyPid's drug-delivery tech combines polymers and lipids. Story

> Vyteris wants to give up the drug-delivery ghost. Item

> Venus Remedies gets EU patent for painkiller injection. Report

> KemPharm's painkiller reduces constipation, abuse risk. Article

Medical Device News

> Study: Medtronic's Infuse can increase male infertility risk. Story

> Kensey Nash picks up Norian assets. News

> Smith out as Angeion CEO. Report

And Finally... Vermont is moving one step closer to a goal of its Democratic governor: a state-run health plan that would insure most of its 625,000 residents. Report