Avastin snubbed yet again by U.K. cost agency

While U.S. regulators debate Roche's Avastin as a breast cancer treatment, U.K. watchdogs aren't even convinced that the drug works well enough against bowel cancer, one of its key indications. The National Institute for Health and Clinical Excellence once again rejected Avastin for use in patients with advanced bowel cancer--in spite of new-and-better pricing from Roche.

The company previously had offered to supply Avastin at a fixed price of £20,800 ($32,430) per patient for one year; the drug would be free after the first 12 months of treatment, and Roche would also reimburse NICE for the cost of accompanying chemo with oxaliplatin. Under the new pricing offer, Roche stuck to this pricing deal, but added an upfront payment to the National Health Service for each patient who started first-line treatment with Avastin, NICE said.

It wasn't enough, NICE chief Andrew Dillon says in a statement: "We are disappointed not to be able to recommend [Avastin]...but we have to be confident that the benefits justify the considerable cost of this drug."

Predictably, the refusal has NICE critics up in arms--including Roche. According to the company, the U.K. "is now virtually the only country in the developed world not to provide Avastin for bowel cancer patients through the state healthcare service," providing "further evidence that the current U.K. reimbursement system is not appropriate for end of life cancer treatments."

- see the NICE statement
- get more from Reuters
- read the Dow Jones coverage

Suggested Articles

WuXi AppTec has appointed Celgene CAR-T program veteran David Chang to lead its cell and gene therapy CDMO, WuXi Advanced Therapies.

Maryland-based Emergent BioSolutions has won a $628 million contract with BARDA to manufacture targeted COVID-19 vaccine hopefuls.

About 76% remdesivir patients had at least one point of clinical improvement on a 7-point scale at day 11, versus 66% of patients on standard care.