Allergan offloads obesity biz for $75M plus milestones; AZ up on broker's advice to shorts;

@FiercePharma: isn't getting post-marketing data on fast-tracked drugs, per JAMA. Required studies undone or unreported. JAMA report | Follow @FiercePharma

@CarlyHFierce: Biogen's Tecfidera drives rosy Q3 results, higher forecast. ICYMI yesterday | Follow @CarlyHFierce

> Allergan ($AGN) agreed to sell its obesity unit to Apollo Endosurgery for $75 million up front, plus a potential $15 million equity interest in the company, plus up to $20 million in milestone payments. Report | FierceMedicalDevices story

> AstraZeneca ($AZN) shares bounced yesterday after Merrill Lynch advised short sellers to close their positions in advance of news on its pipeline drugs; the company reports earnings Thursday. Report

> Hi-Tech Pharmacal settled a class-action lawsuit that claimed its advertising for allergy drug Nasal Ease was misleading. Report

> Brazil's Hypermarcas, a top generics producer in the country, plans to buy back $300 million in bonds to reduce debt. Report

Medical Device News

@FierceMedDev: DOD agency commits $70M to develop brain-monitoring implant. Item | Follow @FierceMedDev

@MarkHFierce: Apollo Endosurgery, a 2012 Fierce 15 winner, aims for big growth by snatching up Allergan's obesity device business. Story | Follow @MarkHFierce

@MichaelGFierce: ICYMI: A blog post from the FDA late last week highlighted the agency's efforts to regulate nanotechnology. Blog | Follow @MichaelGFierce

> St. Jude Medical touts positive preliminary results for Portico heart valve. Article

> Edwards slips as so-so outlook leaves investors underwhelmed. Report

> Covidien flips surgical sealants to Integra for $235M. More

Biotech News

@FierceBiotech: Popular on InVentiv opens U.K. hub as EU demand climbs. Article | Follow @FierceBiotech

@JohnCFierce: The ax drops at troubled Merck as big restructuring gets underway. Story | Follow @JohnCFierce

@DamianFierce: Ex-Calistoga chief Gallagher joins VC Frazier Healthcare to steer biotech bets. News | Follow @DamianFierce

> Sanofi, Glaxo sign up for vaccine R&D projects under new Gates initiative. Story

> Calithera grabs $35M round to fund first slate of cancer drug studies. More

> Eli Lilly partners with Pfizer on its high-risk PhIII pain med tanezumab. News

Pharma Manufacturing News

@EricPFierce: What drugs are up for grabs by generic makers next year? Here's the FiercePharma list of 2014 patent losses. | Follow @EricPFierce

> Wockhardt profits crater after U.S., U.K. plant bans. More

> Manufacturing glitch leaves Novo insulin cartridges with bad fills. Report

> Gilead expanding facility that makes highly anticipated hep C drug. Story

> India's plan to inspect China plants stalled. Article

Biotech Research News

@EmilyMFierce: I took a look at 5 promising preclinical drug programs across industry/academia for this latest report. Feature | Follow @EmilyMFierce

> Fast-acting antidepressants discovered. Report

> New obstacle found in search for HIV/AIDS cure. Item

> Certain microRNAs might be viable Alzheimer's targets. Article

> CytomX 'probody' kills pancreatic cancer cells, leaves healthy tissue intact. Story

And Finally... In almost every European country, bikes are outselling new cars. Report