Telstar completes the pharmaceutical manufacturing and process facilities for B.Braun Spain's new 'LIFT' plant
Telstar carried out the project management under an EPC (Engineering, Procurement and Construction) arrangement.
Telstar has completed the construction of the pharmaceutical manufacturing and process facilities for parenteral solutions in the new LIFT (Lean Infusion Factory Technology) Plant at B. Braun Group's production centre in Spain, which is located in Rubí (Barcelona) and features three production lines.
Telstar carried out the project management of the pharmaceutical manufacturing and process facilities under an EPC (Engineering, Procurement and Construction) arrangement, which enabled direct client involvement in the project's development, particularly in the selection of vendors for the critical phases of the project. Telstar developed the conceptual, basic and detailed engineering phases, coordinated all involved vendors, built the pharmaceutical manufacturing and process facilities, supplied the equipment and performed start-up and validation.
The facilities were designed for a continuous production process, which required the installation of four 30,000 litre manufacturing tanks, and two additional 15,000 litre tanks, to feed three bottling lines with 24/7 production capacity.
Telstar was responsible for the design, installation, start-up and validation of manufacturing tanks with magnetic stirring and interior product recirculation, which ensure a uniform and aseptic production. For the tank loading system, a critical phase of the process, Telstar implemented a custom, bin-to-tank product transfer system, using 'Alpha/Beta'-type high containment valves. Of note in addition to the tanks, is the implementation of the transfer lines from the reactors to the bottling equipment, featuring 'Blow-Fill-Seal' technology and terminal filter systems. Lastly, for the stage of raw materials preparation and unloading into bins, Telstar supplied the weighing booths and Special Airlock Systems (SAS) for materials pass-throughs, as well as a bin washer specifically configured to the requirements of the LIFT manufacturing room.
The pharmaceutical manufacturing and process facilities operate automatically, including management of weighing, in-tank preparation management, traceability of bins in the LIFT manufacturing room, and interconnections to the new LIFT Plant's other automated systems.
B. Braun, a family company of German origin, is an international leader in the development, production, marketing and distribution of medical-surgical materials and pharmaceutical products. With a business history dating back more than 170 years, and 44,000 employees throughout the world, the Company has locations in over 50 countries.
B. Braun Group's new LIFT (Lean Infusion Factory Technology) Plant in Rubí (Barcelona) features a total developed surface area of 30,000 m2. For the Company, this represents a material enhancement of the production capacity of its parenteral solutions, together with the implementation of a high degree of automation. Rubí in Spain and Melsungen in Germany are the Group's two most important production centers of parenteral solutions in Europe.