Dendreon looks to cut manufacturing costs; Express Scripts pays $2.75 million fine;

> Dendreon ($DNDN), which makes prostate cancer drug Provenge, is looking at how to make its manufacturing more efficient since the cost of producing the drug is a drag on earnings. Story

> Contract manufacturer Akela Pharma reported earning $800,000 in the last quarter compared with $3.5 million a year earlier. Item

> Biologics manufacturer Lonza has a new contract to manufacture products for Avalanche Biotechnologies, whose lead wet age-related macular degeneration gene therapy candidate AVA-101 started clinical trials last year. Item

> Fette Compacting has a new tableting center in Campinas, near São Paulo, Brazil. Item

> The pharmacy benefits manager Express Scripts will pay a $2.75 million fine to settle charges that it didn't have adequate provisions in place at distribution centers to prevent employee theft of controlled substances. Story

Webinar

Using AI and RWD to Uncover Rare Disease Insights, Accelerate Commercialization and Improve Patient Outcomes

Wednesday, March 24 | 2pm ET / 11am PT

Learn how IPM.ai transformed real world data into real world insights to assist Audentes in their development of AT132 for the treatment of XLMTM. The session reviews how IPM.ia and Audentes collaborated to uncover the XLMTM patient population.