Titan Pharmaceuticals ($TTNP) now envisions an NDA submission to the FDA for its implantable, controlled release treatment for opioid dependence during its fiscal 2012 third quarter. The South San Francisco-based company announced the news Feb. 9 while promoting encouraging results from a 6-month safety retreatment study of Probuphine, which itself followed encouraging Phase III results released in July. Titan said the drug continues to be well-tolerated, safe and appears to effectively reduce opioid dependence and help control withdrawal and cravings. Probuphine uses Titan's ProNeura continuous drug delivery system, which is implanted under the skin in the upper arm. A patient with the implant gets a 6-month, round-the clock steady dose of the anti-addiction drug buprenorphine (in a new formulation), after which the implant is typically removed or replaced with a new implant. Release