Packaging RNA for long-lasting, nontoxic delivery

Use of RNA for drug delivery has alternatively inspired and frustrated researchers for years. It seems like a perfect tool to deliver therapeutics to targeted cells. The frustrating part is that it is very difficult to produce long-lasting therapeutic RNA that remains stable and non-toxic. One solution, according to Peixuan Guo, of the University of Cincinnati Cancer Nanotechnology Platform Partnership, is use of what is called pRNA (packaging RNA), which can be assembled from two pieces of smaller RNA modules. The pRNA can deliver the gene-silencing siRNA, possibly solving some of the problems that have hindered siRNA for the past decade or so. Read more

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