Listed as number three in pharma sales, GlaxoSmithKline has had some rough luck thanks in part to the diabetes drug Avandia, which has been pulled out of Europe and restricted in the U.S after global side effect concerns since 2007. The company cut its losses on the drug, writing off $233 million in supplies and eliminating its marketing efforts of the drug.

The company has racked up some charges against its earnings, including over $6 billion in the fourth quarter of 2010 from Avandia and marketing settlements. GSK settled 10,000 Avandia lawsuits for a combined $460 million. Also, the company hit number three on FiercePharma's Top Layoffs of 2010 list with 5,201 jobs lost. While other companies look towards more spinoffs, GSK has focused on emerging markets as its ticket to higher revenue. It purchased Laboratorios Phoenix in 2009 and China's MeiRui in 2010; the UK-based company said the impact of its layoffs would be masked by more job opportunities in Asia and South America.

In early 2011, GSK and Human Genome Sciences gained FDA approval for Benlysta, the first new lupus treatment in more than 50 years, and experts believe it could be a $3 billion to $5 billion worldwide sales heyday for the partnership. But the FDA denied an extended approval and a potential $1 billion in sales to GSK from the prostate drug Avodart. While the drug was effective against low-risk malignant tumors, it potentially heightened the risk of developing more aggressive tumors.

GSK spun off its HIV treatments into ViiV Healthcare in 2009, combining it with Pfizer's former R&D efforts in the field. ViiV markets Ziagen, Trizivir, Epzicom and abacavir as part of its suite of drugs for HIV/AIDS.



Latest Headlines

Latest Headlines

BMJ: New analysis shows increased suicide rates in teens taking GSK's Paxil

GlaxoSmithKline has faced its fair share of scrutiny over a study of its antidepressant Paxil in teenagers, with some experts claiming that the company wrote off harmful side effects linked to the med. Now, a re-analysis of the original study shows that the trial trumpeted Paxil's benefits while downplaying serious side effects including suicide.

GSK settles big media review, chooses incumbents for estimated $900M account

And the winner is … everyone. GlaxoSmithKline chose both of its incumbent agencies to continue handling media planning and buying for its newly consolidated GSK Consumer Healthcare business.

Controversial resveratrol triggers new headlines--this time for Alzheimer's

Georgetown's Dr. R. Scott Turner tested a therapeutic grade formulation of resveratrol in Alzheimer's patients, looking at two suspected biomarkers for the disease, the soluble proteins amyloid beta 42 and Abeta 40. Abeta 40 levels remained level among the group getting purified resveratrol, while the control group registered telltale declines as their dementia worsened.

Adaptimmune poaches GSK vet to lead biometrics team

Immuno-oncology player Adaptimmune has dipped into the ranks of its Big Pharma partner GlaxoSmithKline to find a leader for its biometrics team. The move sees Trupti Trivedi join Adaptimmune as VP, head of biometrics.

GSK picks Siemens as preferred supplier of automation tech

GlaxoSmithKline has hitched its automation plans to Siemens. The deal makes Siemens the preferred automation supplier for production and R&D sites at GSK, positioning the conglomerate to shape how its partner incorporates advances in data integration into its operations.

Back-to-school MenB shots are de rigueur at some colleges, but others won't stock them

The Centers for Disease Control immunization committee stopped short of advising routine vaccination against meningitis B, instead leaving the decision up to doctors and families. And now, U.S. universities are tackling MenB vaccination in a multitude of ways.

With limited ACIP nod, U.S. universities take different approaches to Pfizer, GSK MenB jabs

The CDC's Advisory Committee on Immunization Practices has stopped short of recommending routine meningitis B immunization, leaving the decision to doctors and families whether young adults aged 16 to 23 should be vaccinated. Result? U.S. universities are taking varying approaches when it comes to MenB jabs and their students.

Agenus trades adjuvant rights to GSK for $115M to bolster oncology profile

Immunotherapy developer Agenus, looking to further invest in its immuno-oncology pipeline, plans to temporarily cash out of a deal with GlaxoSmithKline to grab $115 million in exchange for royalties it once held on an adjuvant for GSK's malaria and shingles vaccines.

GlaxoSmithKline's hopes flag as Breo flunks COPD outcomes study

GlaxoSmithKline's respiratory business, struggling in the face of Advair price cuts, could use the few billion dollars analysts predicted it could generate if newcomer Breo aced an outcomes study. But no dice, the company reported Tuesday.

UPDATED: On the ropes, GlaxoSmithKline admits to another PhIII debacle

GlaxoSmithKline, which recruited more than 16,000 patients in a monumental postapproval effort to distinguish Breo Ellipta by improving the mortality rates of high-risk patients with COPD, says that study failed.