Generic: Zoledronic acid injection
The company: Novartis ($NVS)
Patent expiration date: March 2, 2013
Estimated Global Sales 2012: $612 million
The scoop: Swiss drugmaker Novartis is bracing itself for a tough few quarters. The company already experienced quite the slump in U.S. sales of its hypertension, heart failure and heart attack drug Diovan since the product's patent expired in September. And 2013 brings more losses; cancer treatment Zometa and osteoporosis treatment Reclast/Aclasta will lose patent protection. Reclast will garner $612 million in estimated sales this year. Novartis is doing what it can to protect its product. In July, the company sued Sun Pharmaceuticals to block it from selling generic forms of Zometa and Reclast. We'll see how that pans out in court.