Exploring ADC Pharmacokinetics Using QSP Modeling Strategies

The Pharmacokinetics (PK) of ADC therapeutics typically show a discrepancy between the PK of total antibody and that of conjugated antibody, carrying one or more payload molecules. This will present how quantitative systems pharmacology modeling approaches provide biological insights into the impact of drug-to-antibody ratio and the resulting changes in molecular properties on overall PK and relative payload disposition as observed in preclinical and clinical studies. Register now!